Methylation of MAP3K2 protein activates key signaling pathway in tumorigenesis

Methylation of MAP3K2 stimulates tumorigenesis
The lab of Biology Professor Or Gozani, in collaboration with the lab of Dr. Julien Sage (Pediatrics and Genetics) and others, showed that SMYD3, a methyltransferase enzyme, methylates MAP3K2, a key component in MAP kinase signaling.  SMYD3 is overexpressed in several human tumors and compromising SMYD3 activity resulted in inhibition of tumors that develop in response to activated RAS oncogene, suggesting that SMYD3 might be a target for cancer therapy. 

Full story published in Nature 510:283-7

Last modified Wed, 20 Aug, 2014 at 23:36

Methylation of MAP3K2 protein activates key signaling pathway in tumorigenesis

Biology Professor Or Gozani and collaborators showed that SMYD3, a methyltransferase enzyme, methylates MAP3K2, a key component in MAP kinase signaling.  SMYD3 is overexpressed in several human tumors and compromising SMYD3 activity resulted in inhibition of tumors that develop in response to activated RAS oncogene, suggesting that SMYD3 might be a target for cancer therapy 

Last modified Wed, 20 Aug, 2014 at 22:54

Welcome to the Department of Biology

Our department includes both undergraduate and graduate programs, with over 110 graduate students and 90 postdoctoral fellows from all over the world.  Research areas include Molecular Biology, Cell Biology, Developmental Biology & Genetics; Plant Biology; Population and Evolutionary Biology and Ecology; and Marine Biology.
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