Gilly Lab

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A newly hatched paralarva of the Humboldt squid, /Dosidicus gigas/, a product of artificial fertilization. The first chromatophores, the ink sac, and eyes can all be easily seen. Also visible is the internal yolk sac that will sustain the hatchling during its first few days of life.
Image courtesy of the Gilly Lab

Last modified Sat, 4 Oct, 2014 at 12:57

McConnell Lab

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A cortical neuron stained for Doublecortin (red), a protein required for normal neuronal migration. In green is antibody staining for the 12E8 monoclonal antibody, which indirectly reveals sites at which kinases such as MARK/PAR1 have phosphorylated target substrate proteins at the sequence KIGS. The staining patterns are completely complementary.
Image courtesy of the McConnell Lab

Last modified Sat, 4 Oct, 2014 at 12:44

Fernald Lab

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Expression of the immediate early gene, egr1 (black silver grains) in gonadotropin releasing hormone (GnRH) containing neurons (brown stain) twenty minutes after social ascent in male cichlid fish, Astatotilapia burtoni. (scale bar = 10 um)
Image courtesy of the Fernald Lab

Last modified Sat, 4 Oct, 2014 at 12:43

Luo Lab

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Apical dendrites from two neighboring pyramidal neurons 3 days after expressing mCD8 alone (red) or expressing both mCD8 (red) and myc-tagged Rac1N17 (green) and therefore appears yellow.
Image courtesy of the Luo Lab

Last modified Sat, 4 Oct, 2014 at 12:02

Long Lab

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A longitudinal section through the tip of an alfalfa nodule infected with a strain of S. meliloti carrying a GFP fusion to the ctrA promoter (green) and stained with propidium iodide (the red color, PI stains nucleic acids, and the rapidly dividing cells of meristem are bright red)
Image courtesy of the Long lab

Last modified Sat, 4 Oct, 2014 at 18:34

Stearns Lab

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The mitotic spindle of a human U2OS cell in metaphase, stained for microtubules (green), DNA (blue) and gamma-tubulin (red). Gamma-tubulin is a specialized tubulin limited to the centrosomes at the poles of the spindle.
Image courtesy of the Stearns Lab

Last modified Sat, 4 Oct, 2014 at 18:35

Conserved modules drive evolution of signaling network

Conserved modules drive evolution of signaling network
Thursday, August 21, 2014
The lab of Professor Martha Cyert, along with collaborators, used phosphoproteomics to systematically uncover targets for the calcium-regulated calcineurin phosphatase in yeast and show that substrate docking sites determine network identity.

Last modified Fri, 5 Sep, 2014 at 11:34

Methylation of MAP3K2 protein activates key signaling pathway in tumorigenesis

Methylation of MAP3K2 stimulates tumorigenesis
Wednesday, August 20, 2014
The lab of Biology Professor Or Gozani, in collaboration with the lab of Dr. Julien Sage (Pediatrics and Genetics) and others, showed that SMYD3, a methyltransferase enzyme, methylates MAP3K2, a key component in MAP kinase signaling.  SMYD3 is overexpressed in several human tumors and compromising SMYD3 activity resulted in inhibition of tumors that develop in response to activated RAS oncogene, suggesting that SMYD3 might be a target for cancer therapy. 

Last modified Sun, 19 Oct, 2014 at 20:56

Methylation of MAP3K2 protein activates key signaling pathway in tumorigenesis

Biology Professor Or Gozani and collaborators showed that SMYD3, a methyltransferase enzyme, methylates MAP3K2, a key component in MAP kinase signaling.  SMYD3 is overexpressed in several human tumors and compromising SMYD3 activity resulted in inhibition of tumors that develop in response to activated RAS oncogene, suggesting that SMYD3 might be a target for cancer therapy 

Last modified Wed, 20 Aug, 2014 at 22:54

Welcome to the Department of Biology

Our department includes both undergraduate and graduate programs, with over 110 graduate students and 90 postdoctoral fellows from all over the world.  Research areas include Molecular Biology, Cell Biology, Developmental Biology & Genetics; Plant Biology; Population and Evolutionary Biology and Ecology; and Marine Biology.
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