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Edward De Robertis is the Norman F. Sprague Chair of Molecular Oncology and an Investigator of the Howard Hughes Medical Institute at UCLA. The De Robertis laboratory studies how long-range cell communication between the dorsal and ventral sides of the embryo occurs through the diffusion of growth factor antagonists. Investigations on the Chordin BMP antagonist showed that facilitated diffusion of a morphogen takes place in the narrow extracellular space that separates the ectodermfrom the endomesoderm. This gradient is further integrated with Wnt signaling through the sequestration of the enzyme GSK3 inside multivesicular endosomes.