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Seema Mattoo, “From Bacteria to Humans - Fic proteins in Cellular Signaling”

January 13, 2020 - 4:00pm to 5:00pm
Clark Center Auditorium S001


Dr. Seema Mattoo is an Assistant Professor in the Department of Biological Sciences at Purdue University, West Lafayette, IN. Her laboratory investigates the functional repertoire of Fic (filamentation induced by cAMP) proteins in regulating prokaryotic and eukaryotic signal transduction pathways. Fic proteins post-translationally modify their protein targets predominantly by adenylylation/AMPylation, which entails the covalent addition of AMP (adenosine monophosphate) to the target. AMPylation has been implicated in processes as diverse as bacterial pathogenesis, protein folding, neurodegeneration, protein translation, and cellular trafficking. Dr. Mattoo received her Ph.D. in Microbiology & Immunology from UCLA, where she studied mechanisms of Bordetella-host interactions with Dr. Jeff F. Miller. As a Howard Hughes Medical Institute Post-Doctoral Fellow with Dr. Jack Dixon at UC-San Diego, Dr. Mattoo co-discovered and characterized an amino acid motif that defines Fic proteins, and elucidated the enzymatic activity of the Fic family of enzymes as evolutionarily conserved adenylyltransferases. At Purdue, Dr. Mattoo’s laboratory identified the Hsp70 chaperone BiP and the pre-synaptic protein alpha-Synuclein as targets of AMPylation, thus establishing a role for Fic proteins in maintaining ER (endoplasmic reticulum) homeostasis and in neurodegeneration.

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